Centre for Cancer Research

Cancer & developmental biology publications

Journal Articles

2010
Buonamici S, Williams J, Morrissey M, Wang A, Guo R, Vattay A, Hsiao K, Yuan J, Green J, Ospina B, Yu Q, Ostrom L, Fordjour P, Anderson DL, Monahan JE, Kelleher JF, Peukert S, Pan S, Wu X, Maira S-M, Garcia-Echeverria C, Briggs KJ, Watkins DN, Yao Y-M, Lengauer C, Warmuth M, Sellers WR, Dorsch M (2010) Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma. Sci Transl Med 2:51ra70.

Cain JE, Di Giovanni V, Smeeton J, Rosenblum ND (2010) Genetics of renal hypoplasia: insights into the mechanisms controlling nephron endowment. Pediatr Res 68:91-98. (Review)

Cooney MA, Malcuit C, Cheon B, Holland MK, Fissore RA, D'Cruz NT (2010) Species-specific differences in the activity and nuclear localization of murine and bovine phospholipase C zeta 1. Biol Reprod 83:92-101.

Hare DJ, George JL, Grimm R, Wilkins S, Adlard PA, Cherny RA, Bush AI, Finkelstein DI, Doble P (2010) Three-dimensional elemental bio-imaging of Fe, Zn, Cu, Mn and P in a 6-hydroxydopamine lesioned mouse brain. Metallomics 2:745-753.

Heffernan C, Whiley PA, Milionis A, Verma PJ, Holland MK, Jans DA, D'Cruz NT (2010) Lineage-specific expression of heterochromatin protein 1gamma in post-compaction, in vitro-produced bovine embryos. Reprod Fertil Dev 22:1022-1031.

Koskimaki JE, Karagiannis ED, Tang BC, Hammers H, Watkins DN, Pili R, Popel AS (2010) Pentastatin-1, a collagen IV derived 20-mer peptide, suppresses tumor growth in a small cell lung cancer xenograft model. BMC Cancer 10:29.

Lin TL, Wang QH, Brown P, Peacock C, Merchant AA, Brennan S, Jones E, McGovern K, Watkins DN, Sakamoto KM, Matsui W (2010) Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926. PLoS One 5:e15262.

Tang BC, Fu J, Watkins DN, Hanes J (2010) Enhanced efficacy of local etoposide delivery by poly(ether-anhydride) particles against small cell lung cancer in vivo. Biomaterials 31:339-344.

Wang DH, Clemons NJ, Miyashita T, Dupuy AJ, Zhang W, Szczepny A, Corcoran-Schwartz IM, Wilburn DL, Montgomery EA, Wang JS, Jenkins NA, Copeland NA, Harmon JW, Phillips WA, Watkins DN (2010) Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia. Gastroenterology 138:1810-1822.

Wilkins S, Billingsley PF (2010) Mosquito cell line glycoproteins: an unsuitable model system for the Plasmodium ookinete-mosquito midgut interaction? Parasit Vectors 3:22. Zhang W, Zeng X, Briggs KJ, Beaty R, Simons B, Chiu Yen RW, Tyler MA, Tsai HC, Ye Y, Gesell GS, Herman JG, Baylin SB, Watkins DN (2010) A potential tumor suppressor role for Hic1 in breast cancer through transcriptional repression of ephrin-A1. Oncogene 29:2467-2476.

Wilkins S, Choglay AA, Chapple JP, van der Spuy J, Rhie A, Birkett CR, Cheetham ME (2010) The binding of the molecular chaperone Hsc70 to the prion protein PrP is modulated by pH and copper. Int J Biochem Cell Biol 42:1226-1232.

2009
Daniel VC, Marchionni L, Hierman JS, Rhodes JT, Devereux WL, Rudin CM, Yung R, Parmigiani G, Dorsch M, Peacock CD, Watkins DN (2009) A primary xenograft model of small-cell lung cancer reveals irreversible changes in gene expression imposed by culture in vitro. Cancer Res 69:3364-3373.

Jiang T, Collins BJ, Jin N, Watkins DN, Brock MV, Matsui W, Nelkin BD, Ball DW (2009) Achaete-scute complex homologue 1 regulates tumor-initiating capacity in human small cell lung cancer. Cancer Res 69:845-854.

2008
Briggs KJ, Corcoran-Schwartz IM, Zhang, W, Harcke T, Devereux WL, Baylin SB, Eberhart CG, Watkins DN (2008). Cooperation between the Hic1 and Ptch1 Tumor Suppressors in Medulloblastoma. Genes & Development, 22:770-785 Selected as Editor’s Choice in Science Signaling. A. VanHook, Hh and BMP Converge on Atoh1. Sci. Signal. 1, ec111 (2008)

Hann CL, Daniel VC, Sugar EA, Dobromilskaya I, Murphy SC, Cope L, Lin X, Hierman JS, Wilburn DL, Watkins DN, Rudin CM (2008). Therapeutic efficacy of ABT-737, a selective inhibitor of Bcl-2, in small cell lung cancer. Cancer Res, In press

Matsui W, Wang Q, Barber J, Brennan S, Smith BD, Borello I, McNiece I, Lin L, Ambinder R, Peacock C, Watkins DN, Huff CA, Jones RJ (2008). Clonogenic Multiple Myeloma Progenitors, Stem Cell Properties, and Drug Resistance. Cancer Res, 1;68(1):190-7

Zhang W, Glockner S, Guo M, Machida E, Wang D, Easwaran H, Van Neste L, Herman JG,  Schuebel K, Watkins N, Ahuja N,  Baylin S (2008). Epigenetic inactivation of the canonical Wnt antigonist SOX17 in colorectal cancer. Cancer Res. 68(8):2764-72.


2007
Biankin SA, Collector MI, Biankin AV, Brown LJ, Kleeberger W, Devereux WL, Zahnow CA, Baylin SB, Watkins DN, Sharkis SJ, Leach SD (2007). A histological survey of green fluorescent protein expression in 'green' mice: implications for stem cell research. Pathology. Apr;39(2):247-51.

Nikolaidis N, Chalkia D, Watkins DN, Barrow RK, Snyder SH, van Rossum DB, Patterson RL (2007). Ancient Origin of the New Developmental Superfamily DANGER. PLoS One. 2:e204-7.

Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, Cope L, Mohammad HP, Chen W, Daniel VC, Yu W, Berman DM, Jenuwein T, Pruitt K, Sharkis SJ, Watkins DN, Herman JG, Baylin SB. A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet, 2007; 39:237-42. Epub 2007 Jan 9.

Peacock CD, Wang Q, Gesell GS, Corcoran-Schwartz IM, Jones E, Kim J, Devereux WL, Rhodes JT, Huff CA, Beachy PA, Watkins DN*, Matsui W* (2007). Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. Proc Natl Acad Sci USA, 104:4048-53. Epub 2007 Feb 27. *Co-corresponding author with equal contribution.

Reddy PS, Burroughs KD, Hales LM, Ganesh S, Jones BH, Idamakanti N, Hay C, Li SS, Skele KL, Vasko AJ, Yang J, Watkins DN, Rudin CM, Hallenbeck PL. Seneca Valley Virus, a Systemically Deliverable Oncolytic Picornavirus, and the Treatment of Neuroendocrine Cancers. J Natl Cancer Inst. Oct 30; 99: 1623–33

Watkins DN, Herman JG, Baylin SB (2007). A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet, 39:237-42. Epub 2007 Jan 9.


2006
Pruitt K, Zinn RL, Ohm JE, McGarvey KM, Kang SH, Watkins DN, Herman JG, Baylin SB (2006). Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet, 2:e40. Epub 2006 Mar 31.

van Rossum DB, Patterson RL, Cheung KH, Barrow RK, Syrovatkina V, Gessell GS, Burkholder SG, Watkins DN, Foskett JK, Snyder SH (2006). DANGER, a novel regulatory protein of inositol 1,4,5-trisphosphate-receptor activity. J Biol Chem, 281:37111-6. Epub 2006 Sep 21.


2004
Suzuki H, Watkins DN, Jair KW, Schuebel KE, Markowitz SD, Chen WD, Pretlow TP, Yang B, Akiyama Y, von Engeland M, Toyota M, Tokino T, Hinoda Y, Imai K, Herman JG and Baylin SB (2004). Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer. Nat Genet, 36:417-422.


2003
Akayama Y, Watkins DN, Suzuki H, Jair KW, van Engelund M, Esteller M, Sakai H, Chun-Yan R, Yuasa Y, Herman JG, Baylin SB (2003). GATA-4 and GATA-5 transcription factor genes and potential anti-tumor target genes are epigenetically silenced in colorectal and gastric cancer. Mol Cell Biol, 425:846-851.

Berman DM, Karhadkar SS, Maitra A, Montes de Oca R, Gerstenblith MR, Briggs K, Parker AR, Shimada Y, Eshleman JR, Watkins DN, Beachy, PA (2003). Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature, 425:846-851.

Chen WY, Zeng X, Carter MG, Morrell CN, Chiu Yen RW, Esteller M, Watkins DN, Herman JG, Mankowski JL, Baylin SB (2003). Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors. Nat Genet, 33:197-202.

Watkins DN*, Berman DM, Burkholder SG, Wang B, Beachy PA, Baylin SB (2003). Hedgehog Signalling Within Airway Epithelial Progenitors and in Small Cell Lung Cancer. Nature, 422:313-317. *Corresponding Author.


Reviews

2008
Briggs KJ, Eberhart CG, Watkins DN (2008) Just say no to ATOH: how HIC1 methylation might predispose medulloblastoma to lineage addiction. Cancer Res 68:8654-8656.

Peacock CD, Watkins DN. Cancer stem cells and the ontogeny of lung cancer  (2008). J Clin Oncol 26:2883-2889.

Rudin CM, Hann CL, Peacock CD, Watkins DN (2008) Novel systemic therapies for small cell lung cancer. J Natl Compr Canc Netw 6:315-322.

2007
Lam WK, Watkins DN (2007). Lung Cancer: Future Directions. Respirology, 12(4):471-7.


2006
Daniel VC, Peacock CD, Watkins DN. Developmental signalling pathways in lung cancer (2006). Respirology. May;11(3):234-40.


2003
Watkins DN^*, Berman DM, Baylin SB (2003). Hedgehog Signaling: Progenitor Phenotype in Small Cell Lung Cancer. Cell Cycle, 2:196-198 ^*Corresponding Author


Book chapters
Dobb GJ, Watkins DN. Nutritional Failure. “Intensive Care Traps and Tricks” Park, GR and Pinsky MJ eds. WB Saunders, New York 1997