Centre for Cancer Research

Cancer metastases publications

2010
Barnes EC, Said NABM, Williams ED, Hooper JNA, Davis RA (2010) Ecionines A and B, two new cytotoxic pyridoacridine alkaloids from the Australian marine sponge, Ecionemia geodides. Tetrahedron 66:283-287.

Manuelpillai U, Tchongue J, Lourensz D, Vaghjiani V, Samuel CS, Liu A, Williams ED, Sievert W (2010) Transplantation of human amnion epithelial cells reduces hepatic fibrosis in immunocompetent CCl-treated mice. Cell Transplant 19:1157-1168.

Moodley Y, Ilancheran S, Samuel C, Vaghjiani V, Atienza D, Williams ED, Jenkin G, Wallace E, Trounson A, Manuelpillai U (2010) Human amnion epithelial cell transplantation abrogates lung fibrosis and augments repair. Am J Respir Crit Care Med 182:643-651.

2009
Balanathan P, Williams ED, Wang H, Pedersen JS, Horvath LG, Achen MG, Stacker SA, Risbridger GP (2009) Elevated level of inhibin-alpha subunit is pro-tumourigenic and pro-metastatic and associated with extracapsular spread in advanced prostate cancer. Br J Cancer 100:1784-1793.

Coso S, Williams ED (2009) Prostate cancer lymph node metastasis. Open Prostate Cancer J 2:16-31. (Review)

Kaminskas LM, Kelly BD, McLeod VM, Boyd BJ, Krippner GY, Williams ED, Porter CJH (2009) Pharmacokinetics and tumor disposition of PEGylated, methotrexate conjugated poly-L-lysine dendrimers. Mol Pharm 6:1190-1204.

Maddaluno L, Verbrugge SE, Martinoli C, Matteoli G, Chiavelli A, Zeng Y, Williams ED, Rescigno M, Cavallaro U (2009) The adhesion molecule L1 regulates transendothelial migration and trafficking of dendritic cells. J Exp Med 206:623-635.

Said NABM, Williams ED (2009) Remodelling the malignant phenotype: impact of EMT. Drug Discov Today: Dis Model 6:21-25. (Review)

Slomiany MG, Dai L, Tolliver LB, Grass GD, Zeng Y, Toole BP (2009) Inhibition of functional hyaluronan-CD44 interactions in CD133-positive primary human ovarian carcinoma cells by small hyaluronan oligosaccharides. Clin Cancer Res 15:7593-7601.

Williams ED (2009) Lymphatic vessels. In Encyclopedia of Cancer, 2^nd Edition. Schwab M, editor. Heidelberg, Germany: Springer. pp 1730-1731. (Review)

2008
O'Brien PM, Davies MJ, Scurry JP, Smith AN, Barton CA, Henderson MJ, Saunders DN, Gloss BS, Patterson KI, Clancy JL, Heinzelmann-Schwarz VA, Murali R, Scolyer RA, Zeng Y, Williams ED, Scurr L, DeFazio A, Quinn DI, Watts CKW, Hacker NF, Henshall SM and Sutherland RL (2008) The E3 ubiquitin ligase EDD is an adverse prognostic factor for serous epithelial ovarian cancer and modulates cisplatin resistance in vitro. Br J Cancer 98:1085-1093.

Reviews
Bernkopf DB and Williams ED (2008) Potential role of EPB41L3 (Protein 4.1B/Dal-1) as a target for treatment of advanced prostate cancer. Expert Opin Ther Targets 12(7):845-853.

Thompson EW and Williams ED (2008) EMT and MET in carcinoma-clinical observations, regulatory pathways and new models. Clin Exp Metastasis;25(6):591-592.

2007
Chaffer CL, Dopheide B, Savagner P, Thompson EW and Williams ED (2007)Aberrant fibroblast growth factor receptor signaling in bladder and other cancers. Differentiation 75(9):831-842.

Chaffer CL, Thompson EW and Williams ED (2007) Mesenchymal to epithelial transition in development and disease. Cells Tissues Organs 185(1-3):7-19.

Horvath LG, Lelliott JE, Kench JG, Lee CS, Williams ED, Saunders DN, Grygiel JJ, Sutherland RL and Henshall SM (2007) Secreted frizzled-related protein 4 inhibits proliferation and metastatic potential in prostate cancer. Prostate 67(10):1081-1090.

Hugo H, Ackland ML, Blick T, Lawrence MG, Clements JA, Williams ED and Thompson EW (2007) Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression. J Cell Physiol 213(2):374-383.

2006
Chaffer CL, Brennan JP, Slavin JL, Blick T, Thompson EW and Williams ED (2006)Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2. Cancer Res 66(23):11271-11278.

Chaffer CL, Thomas DM, Thompson EW and Williams ED (2006) PPARgamma-independent induction of growth arrest and apoptosis in prostate and bladder carcinoma. BMC Cancer 6:53-64.

Zeng Y, Opeskin K, Goad J and Williams ED (2006) Tumor-induced activation of lymphatic endothelial cells via vascular endothelial growth factor receptor-2 is critical for prostate cancer lymphatic metastasis. Cancer Res 66(19):9566-9575.

2005
Chaffer CL, Dopheide B, McCulloch DR, Lee AB, Moseley JM, Thompson EW and Williams ED (2005) Upregulated MT1-MMP/TIMP-2 axis in the TSU-Pr1-B1/B2 model of metastatic progression in transitional cell carcinoma of the bladder. Clin Exp Metastasis 22:115-125.

Hammacher A, Thompson EW and Williams ED (2005) Interleukin-6 is a potent inducer of S100P, which is up-regulated in androgen-refractory and metastatic prostate cancer. Int J Biochem Cell Biol 37:442-450.

Lafleur MA, Drew AF, de Sousa EL, Blick T, Bills M, Walker EC, Williams ED, Waltham M and Thompson EW (2005) Upregulation of matrix metalloproteinases (MMPs) in breast cancer xenografts: a major induction of stromal MMP-13. Int J Cancer 114:544-554.

McCulloch DR, Opeskin K, Thompson EW and Williams ED (2005) BM18: a novel androgen-dependent human prostate cancer xenograft model derived from a bone metastasis. Prostate 65:35-43.

Zeng Y, Opeskin K, Horvath LG, Sutherland RL and Williams ED (2005) Lymphatic vessel density and lymph node metastasis in prostate cancer. Prostate 65:222-230.

Zeng Y, Wang F, Williams ED and Chow CW (2005) Lymphatics in the alimentary tract of children in health and disease: study on mucosal biopsies using the monoclonal antibody d2-40. Pediatr Dev Pathol 8:541-549.

2004
Sharp JA, Waltham M, Williams ED, Henderson MA and Thompson EW (2004) Transfection of MDA-MB-231 human breast carcinoma cells with bone sialoprotein (BSP) stimulates migration and invasion in vitro and growth of primary and secondary tumors in nude mice. Clin Exp Metastasis 21:19-29.

Thompson EW, Waltham M, Ramus SJ, Hutchins AM, Armes JE, Campbell IG, Williams ED, Thompson PR, Rae JM, Johnson MD and Clarke R (2004) LCC15-MB cells are MDA-MB-435: a review of misidentified breast and prostate cell lines. Clin Exp Metastasis 21:535-541.

Zeng Y, Opeskin K, Baldwin ME, Horvath LG, Achen MG, Stacker SA, Sutherland RL and Williams ED (2004) Expression of vascular endothelial growth factor receptor-3 by lymphatic endothelial cells is associated with lymph node metastasis in prostate cancer. Clin Cancer Res 10:5137-5144.

2003
Chandler JD, Williams ED, Slavin JL, Best JD and Rogers S (2003) Expression and localization of GLUT1 and GLUT12 in prostate carcinoma. Cancer 97:2035-2042.

Macheda ML, Williams ED, Best JD, Wlodek ME and Rogers S (2003) Expression and localisation of GLUT1 and GLUT12 glucose transporters in the pregnant and lactating rat mammary gland. Cell Tissue Res 311:91-97.